Introduction to high throughput screening - 2 ECTS

Web-based course organised by LCBU, Department of Chemistry, Umeå University. This course is organised continuous. The course has no on-campus activities

Important dates:

  • Application open: November 13, 2017
  • Application deadline: No deadline

Responsible teacher/s:
Stina Berglund and Mikael Elofsson
Department of Chemistry, Umeå University

Contact information for questions regarding the course: stina.berglund01@umu.se

Course content
The course gives a broad introduction to high throughput screening (HTS) that is technique used to identify biologically active small organic molecules through screening of compound libraries with the help of robust test systems and advanced instrumentation.

Participants can start at any time and study at their own pace since the course is entirely web-based. The course material is in English consisting of text and explanatory figures, video lectures, review articles, and movies.

The course includes a description of small organic molecules as research tools and starting points for drug development. In addition different parameters to consider when designing a compound collection for HTS will be reviewed. Biological activity is most cases that the organic molecule affect a protein or other biomolecule. The course describes development of robust and statistically validated test systems that allow biological activity to be measured by e.g. luminescence, absorbance, or fluorescence. The most common instruments for liquid handling and reading of the test system signal will be reviewed. The course also covers how HTS is performed and how molecules that are identified as potentially actives are followed up by analysis of analogs and additional test systems. HTS generates large amounts of data and the course briefly reviews the important role that an informatics system has. The course also covers a number of special topics and case studies to illustrate the application of HTS.

Entry requirements: Bachelor degree (120 ECTS) in chemistry, molecular biology, pharmacology or equivalent. English knowledge corresponding to the Swedish upper secondary education English B.

For more information and registration: http://www.chemistry.umu.se/english/research/infrastructure/lcbu/training-and-education/


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